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KMID : 0352519930300010309
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Korea Univercity Medical Journal
1993 Volume.30 No. 1 p.309 ~ p.318
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Experimental Study About Effects of Nasal Hyperreactivity on the Eustachian Tube Obstruction
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Abstract
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The clinical studies that nasal diseases including allergic rhinitis or chronic rhinosinusitis participate in the pathogenesis of OME have been reported. A higher prevalence of OME in patiets with rhinitis can be seen frequently in daily clinical
practice.
Some hypotheses that the middle ear mucosa has the potential to function as an allergic shock organ were reproted, however, biochemical and cytological studies to substantite the allergic reaction in the middle ear effusion and mucosa did not
confirm
this theory. Since then, a relationship between allergic rhinitis and functional obstruction of eustachian tube has been reported as a result of several studies provocating nasal hyperreactivity in experimental allergic rhinitis or allergic
rhinitis
patients.
These studies focused on the functional aspect of eustachina tube obstruction but, didn's confirm the morphological evidence about narrowing of the lumen. The purpose of this study was to evaluate whether the vascular permeability in eustachan
tube
mucosa in nasal hyperreactivity is increased.
In nasal hyperreactivity group, the vascular permeability in mucosa of nasopharyngeal opening and cartilginous portion of eustachian tube was increased compared with control group, but that in tubotympanic portion was not increased. The
eosinophil
was
observed in nasal mucosa, nasopharyngeal mucosa and nasopharyngeal portion of eustachian tube but not observed in mucosa of cartilaginous portion of eustachian tube.
Above findings confirmed that the provocation of nasal hyperreactivity may participate in the edema formation in mucosa of cartilaginous and nasopharvngeal portion of eustachian tube as well as nasopharyngeal mucosa.
The edema formation in mucosa of nasopharynx and nasopharyngeal portion of eustachian tube may occur by direct reaction of nasal hyperreactivity by that in mucosa of cartilaginous portion of eustachian tube seems to develop by some other pathway.
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KEYWORD
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